Definition of Metabolic Syndrome

  • NHLBI/AHA Conference Proceedings
TABLE 1. ATP III Clinical Identification of the Metabolic Syndrome
Risk Factor Defining Level
*Overweight and obesity are associated with insulin resistance and the metabolic syndrome. However, the presence of abdominal obesity is more highly correlated with the metabolic risk factors than is an elevated BMI. Therefore, the simple measure of waist circumference is recommended to identify the body weight component of the metabolic syndrome.
†Some male patients can develop multiple metabolic risk factors when the waist circumference is only marginally increased, eg, 94 to 102 cm (37 to 39 in). Such patients may have a strong genetic contribution to insulin resistance. They should benefit from changes in life habits, similarly to men with categorical increases in waist circumference.
‡The American Diabetes Association has recently established a cutpoint of ≥100 mg/dL, above which persons have either prediabetes (impaired fasting glucose) or diabetes.14 This new cutpoint should be applicable for identifying the lower boundary to define an elevated glucose as one criterion for the metabolic syndrome.
Abdominal obesity, given as waist circumference*
    Men >102 cm (>40 in)
    Women >88 cm (>35 in)
Triglycerides ≥150 mg/dL
HDL cholesterol
    Men <40 mg/dL
    Women <50 mg/dL
Blood pressure ≥130/≥85 mm Hg
Fasting glucose ≥110 mg/dL

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